Why Sacred Plant Co's Osha Root Tincture Reigns Supreme
Last Updated: April 26, 2026
Sacred Plant Co's Osha Root Tincture is a year-long, alcohol-free glycerite crafted through our proprietary Eternal Extraction Method, with four lunar-cycle infusions in food-grade vegetable glycerin to capture the resinous celery-pepper-anise aromatic profile that signals authentic, potent Bear Root.
The first thing you notice is the smell. Crack the seal on a bottle of properly prepared Osha Root (Ligusticum porteri) extract and a wave of resinous warmth rolls out, a sharp celery-pepper bite laced with anise sweetness, a scent so assertive it practically vibrates. If your Osha tincture smells like nothing, like faintly sweetened water, that is your answer before you even take a drop. It is not working. Real Osha bites back because the volatile oils that create that piercing aroma, the Z-ligustilide, the butylidenephthalide, the terpene-rich essential oil fraction, are the same compounds responsible for its traditional reputation in supporting respiratory wellness and seasonal comfort.1
That aroma is not accidental. It is the chemical signature of a plant that grew slowly in high-altitude soil alive with mycorrhizal fungi, endophytic bacteria, and the kind of microbial diversity that compels a root to produce concentrated secondary metabolites as part of its own survival strategy. At Sacred Plant Co, we understand this connection at a fundamental level. Our regenerative philosophy, rooted in Korean Natural Farming (KNF) methods at I·M·POSSIBLE Farm, focuses on cultivating exactly this kind of soil biology. The result: documented 400% increases in soil biological activity, measured through independent laboratory testing. When soil is alive, plants produce chemistry created by struggle, not comfort, and you can smell the difference in every drop. See the Regen Ag Lab microbial activity data behind our approach.
If it doesn't bite back, it's not working. That principle guides everything we do at Sacred Plant Co, from sourcing decisions to our proprietary year-long extraction process. This guide will walk you through the phytochemistry behind authentic Osha Root, why our Eternal Extraction Method produces a glycerite unlike anything else on the market, and how to use it thoughtfully in your own wellness practice. For the complete biochemical foundation behind Bear Root's full compound spectrum, our complete science-based guide to Bear Root benefits and therapeutic uses covers the full phthalide spectrum, terpenes, ferulic acid, and synergistic compound interactions in depth.
What You'll Learn
- The specific phthalide compounds (Z-ligustilide, butylidenephthalide, diligustilide) that drive Osha Root's traditional respiratory reputation and how soil biology influences their concentration
- How Sacred Plant Co's year-long Eternal Extraction Method with four lunar-cycle infusions produces a more complex glycerite than standard quick-maceration tinctures
- Sensory quality markers (color, aroma intensity, resinous texture) to distinguish premium Osha extract from diluted or degraded products
- Evidence-based preparation methods and dosage guidelines for tinctures, teas, and syrups with safety considerations
- Why Osha's slow growth, wild-harvested status, and conservation challenges make responsible sourcing a non-negotiable quality factor
- Comprehensive safety profile including contraindications during pregnancy, hemlock look-alike risks, and proper identification protocols
- How to request and interpret Certificates of Analysis (COA) for herbal extracts to verify potency and purity
- Strategic pairing suggestions with complementary respiratory herbs like Mullein and Echinacea for comprehensive seasonal wellness
Botanical Profile and Phytochemistry of Osha Root
Osha Root (Ligusticum porteri) is a high-altitude perennial herb in the Apiaceae (carrot) family, native to subalpine meadows and conifer forest edges at elevations between 8,000 and 11,000 feet.
The plant produces large compound leaves resembling its relatives parsley and angelica, clusters of small white flowers in summer, and a substantial aromatic taproot that takes five to seven years to reach peak maturity. It is this extended maturation period in cold, biologically active mountain soils that allows the root to accumulate the therapeutic concentrations of volatile oils and phthalides that traditional herbalists prize.2
Also called Bear Root, Porter's Lovage, Mountain Lovage, and Chuchupate in Mexican herbal traditions, Osha has deep ethnobotanical roots across Indigenous communities of the high mountain west and the high-desert Southwest. Apache, Navajo, Zuni, and Pueblo peoples have utilized Bear Root for generations as both medicine and ceremonial herb. The common name "Bear Root" comes from traditional observations of bears digging up and consuming the roots after emerging from hibernation.3
Key Bioactive Compounds
Modern phytochemical analysis has identified several distinct classes of bioactive compounds in Osha Root that work synergistically:
- Phthalides (comprising over 44% of the essential oil): Z-ligustilide is the dominant monomeric phthalide and the most thoroughly studied for biological activity. Additional phthalides include Z-butylidenephthalide, diligustilide, tokinolide B, riligustilide, and senkyunolides F and I.1
- Phenolic acids: Ferulic acid and caffeic acid contribute antioxidant and anti-inflammatory activity.4
- Monoterpenes: Alpha-pinene, beta-pinene, limonene, and sabinyl acetate contribute to the root's distinctive aromatic profile and offer their own therapeutic properties.
- Coumarins and furanocoumarins: Present in smaller concentrations, contributing to the root's complex pharmacological profile.2
Critically, HPLC analysis has revealed that phthalide content varies dramatically between samples, with Z-ligustilide concentrations ranging from 0.15% to 2.5% depending on growing conditions, harvest timing, and post-harvest processing.5 This variability underscores why sourcing quality and extraction methods matter profoundly. Research on distinct chemotypes of L. porteri has shown that roots from certain regions contain more than double the Z-ligustilide of roots from other areas, and these differences carry direct implications for therapeutic use.6
Dive Deeper into Osha Phytochemistry: Our comprehensive Bear Root science guide explores every compound class in detail, from phthalide biosynthesis to immune modulation pathways, and is the cluster pillar for everything Osha-related at Sacred Plant Co. Read the full Bear Root benefits and science guide.
Traditional Uses and Scientific Research
Osha Root's most extensively documented traditional application centers on respiratory wellness, where it has been used as both an expectorant and a bronchial-supporting herb in folk practice for centuries.
Indigenous communities reached for Bear Root at the first signs of seasonal respiratory challenges, particularly chest congestion, productive cough, or throat irritation. In Mexican folk medicine, Chuchupate is similarly valued for respiratory support and digestive ease.3
Modern laboratory research, while still predominantly preclinical, has begun to explore several traditional applications:
- Respiratory support: Phthalide compounds have demonstrated the ability to relax smooth muscle tissue, including bronchial passages, in laboratory models. This spasmolytic action may help support comfortable breathing. Several dimeric phthalides from L. porteri displayed both sedative and spasmolytic properties in validated laboratory models.1
- Antimicrobial activity: The essential oil of L. porteri shows significant activity against several bacterial strains in laboratory settings, including Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Bacillus cereus.7
- Anti-inflammatory effects: Z-ligustilide has demonstrated the ability to reduce pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-17 in preclinical models. Doses of 20 mg/kg/day reduced inflammatory markers within 24 hours in endotoxin-challenged animal models.8
- Antioxidant support: L. porteri root extract may support antioxidant defenses by increasing glutathione (GSH) levels and supporting the activity of superoxide dismutase (SOD) and catalase (CAT) enzymes in laboratory models.9
- Gastroprotective effects: Diligustilide isolated from L. porteri roots demonstrated protective effects against ethanol-induced gastric lesions in animal models.10
Important context: While these findings are promising, most research on L. porteri specifically remains at the test-tube and animal study level. Much of the supporting evidence comes from studies on the closely related Asian species L. chuanxiong, used extensively in Traditional Chinese Medicine. Human clinical trials specific to Osha Root are limited. This does not diminish its centuries of traditional use, but it does mean we should frame any potential applications with appropriate nuance.
How to Identify Premium Osha Root Extract
Premium Osha Root extract is immediately identifiable through three sensory markers: a deep amber-to-golden color, a potent resinous aroma with distinct celery-pepper-anise notes, and a warming, slightly sweet glycerite body with lingering spice on the palate.
Sensory Quality Markers for Osha Glycerite
Aroma intensity: Open the bottle and inhale. Premium Osha extract should deliver an immediate, assertive wave of celery-like pungency layered with peppery warmth and a sweet anise undertone. Sacred Plant Co's tasting notes name three dominant markers: celery, pepper, and anise. If the aroma is faint, watery, or primarily sweet with no resinous bite, the extract likely contains insufficient volatile oil content.
Color: Look for a deep amber to warm golden hue, indicating thorough extraction of both aromatic and heavier molecular-weight constituents. Pale, nearly clear extracts suggest short maceration times or excessive dilution. Overly dark, murky extracts may indicate oxidation or degraded plant material.
Taste profile: On the tongue, quality Osha glycerite should open sweet (from the glycerin base), then quickly transition to a warming, peppery bite with resinous depth. The finish should linger with a mild numbing or tingling sensation on the back of the throat, a hallmark of concentrated phthalide content.
Texture and clarity: A well-made glycerite should be moderately viscous, smooth, and free of sediment or floating particulates. Slight natural haze is acceptable in artisanal extracts, but gritty residue suggests inadequate filtration.
Drying and processing methods dramatically affect the final compound profile. Research shows that drying at high temperatures significantly decreases concentrations of Z-ligustilide and other major phthalides while increasing oxidation products.11 This is why the care taken during sourcing, drying, and extraction directly determines whether you end up with potent extract or aromatic water.
The Eternal Extraction Method: How We Craft Our Osha Glycerite
Sacred Plant Co's proprietary Eternal Extraction Method is a year-long, four-phase process that produces an alcohol-free Osha Root glycerite with exceptional aromatic complexity and batch-to-batch consistency.
Where most commercial tinctures rely on quick alcohol-based macerations completed in weeks, our method takes a fundamentally different approach. We start with carefully sourced, vibrant Osha Root, clean and prepare the material by hand, and settle it into food-grade vegetable glycerin at a ratio designed to favor both volatile aromatic compounds and broader-spectrum constituents.
Four Lunar Cycles of Layered Infusion
At each full moon across four consecutive cycles, we layer in fresh plant material to refresh the solvent phase and deepen the extract's profile. This layered approach builds complexity by introducing phytochemical diversity from different portions of root material while the glycerin continues drawing compounds from earlier additions.
Twelve Months of Slow Maturation
Rather than pressing and bottling after a few weeks, we allow the full maceration to continue for twelve months. During this time, we protect the extract from heat and excess light, minimize oxygen exposure, and follow a cadence of gentle agitation, more frequent in the early weeks, then tapering to a set schedule. This extended timeline allows heavier molecular-weight compounds like dimeric phthalides to fully transfer into solution.
Glycerin Base, Not Alcohol
We use a vegetable-glycerin base for a smooth, naturally sweet, alcohol-free experience that many people prefer for daily routine use. Glycerites integrate easily into family wellness practices and evening protocols where alcohol content is undesirable.
Final Processing
At the end of the cycle, we taste and evaluate, then slowly press the marc. The resulting fractions rest, marry, and are filtered in stages for clarity without stripping aromatic character. Only then do we bottle in amber glass, label with harvest details and batch codes, and release the finished glycerite.
Note: Lunar timing reflects traditional craft perspectives valued by many herbalists. Outcomes vary by individual and routine.
Learn the Full Process: Our Eternal Extraction Method applies to every tincture we craft, not just Osha. Explore the Eternal Extraction Method in detail to understand why time is the strongest tool in the room.
Osha Root Tincture - Eternal Extraction Glycerite
Year-long, four-phase Eternal Extraction in vegetable glycerin. Alcohol-free. Crafted with responsibly sourced Ligusticum porteri root for maximum aromatic complexity and batch-to-batch consistency.
View Product
Whole Osha Root - Bear Root
Responsibly sourced whole Ligusticum porteri root for DIY teas, decoctions, syrups, and tinctures. Ideal for herbalists who prefer working directly with raw plant material.
View ProductPreparation Methods and Dosage Guidelines
The standard dosage range cited in herbal references for Osha Root glycerite is 10 to 30 drops (approximately 0.5 to 1.5 mL) taken one to three times daily, added to warm water, tea, or juice, or placed directly under the tongue. Start with the lower end and adjust based on your body's response. Consult a qualified healthcare practitioner for personalized guidance.
Tincture/Glycerite (Ready-to-Use)
Our Osha Root glycerite is the most convenient format. Simply measure your drops with the included dropper, add to a small amount of warm water or herbal tea to dilute the sweetness if preferred, and take. Many practitioners recommend using Osha glycerite at the very first signs of seasonal respiratory challenges rather than waiting until symptoms are fully established.
Decoction (Whole Root Tea)
For those who prefer working with whole root, simmer 1 to 2 teaspoons of cut root in 2 cups of water for 15 to 20 minutes, covered, to retain volatile oils. Strain and sip warm. Because Osha's volatile compounds can evaporate during boiling, keeping the pot covered is essential. For full brewing methodology and four detailed preparation techniques, see our complete guide to brewing Osha Root tea.
Osha Syrup
Osha syrup combines decocted root with honey for a shelf-stable, palatable preparation especially suited to seasonal wellness routines. The honey adds its own demulcent properties while making the intensely aromatic Osha more approachable for the whole family.
Make Your Own: Our step-by-step guide covers the complete process from decoction to bottling, including tips for extending shelf life and customizing with complementary herbs. Get the full Osha Syrup recipe.
Ritual and Intention
At Sacred Plant Co, we believe that the act of preparing and taking herbal extracts is itself a practice. Whether you are measuring drops of glycerite into morning tea or simmering root on the stove, bring awareness to the process. Notice the aroma. Feel the warmth. This is not mysticism for its own sake. It is a recognition that mindful engagement with plant practices has been part of human wellness across cultures and centuries.
Responsible Sourcing and Conservation
Osha is a slow-growing, primarily wild-harvested plant on the United Plant Savers At-Risk list, making responsible sourcing a non-negotiable factor in both quality and ethics.
Unlike cultivated herbs that can be replanted seasonally, Osha Root requires five to seven years of slow growth in specific high-altitude conditions to reach medicinal maturity. Cultivation attempts remain limited and largely unsuccessful at commercial scale.
This reality places significant conservation pressure on wild populations. At Sacred Plant Co, we emphasize procurement practices that support selective, conservation-minded harvesting. We prioritize suppliers who demonstrate responsible harvest protocols, including leaving Grandmother Roots intact for population regeneration and avoiding overharvesting from any single site. For the complete framework of sustainable wildcrafting principles, the six-question supplier verification protocol, and the Indigenous stewardship traditions behind ethical Osha harvest, see our dedicated guide on ethical Osha Root sourcing and Indigenous stewardship.
We view this as an extension of our regenerative philosophy. The same thinking that drives our KNF soil-building practices at I·M·POSSIBLE Farm, respect for biological systems, long-term stewardship over short-term extraction, applies equally to how we approach wild-harvested materials like Osha.
Safety Considerations: Contraindications and Energetics
Osha Root is generally well-tolerated by most adults when used at recommended dosages, but carries specific contraindications that warrant careful attention, particularly around pregnancy and plant identification.
Important Safety Information
Medical Contraindications
- Pregnancy and nursing: Osha has traditionally been used as an emmenagogue (a substance associated with menstrual flow) and is classified as Safety Class 2B by the Botanical Safety Handbook, meaning it should be avoided during pregnancy except under direct supervision of a qualified healthcare practitioner.3
- Kidney conditions: Due to potent aromatic constituents, caution is advised for individuals with kidney disease.
- Children: Consult a qualified herbalist or pediatric practitioner before giving Osha to children, especially infants and toddlers.
- Medications: If you are taking prescription medications, consult your healthcare provider before adding Osha to your routine, particularly if using blood-thinning medications or medications affecting blood sugar.
Critical Identification Warning
Osha can be confused with poison hemlock (Conium maculatum) and water hemlock (Cicuta maculata), both of which are highly toxic and potentially fatal. The most reliable identification marker is the root itself: Osha roots are dark brown, wrinkled, and emit a strong celery-like aroma when broken. Hemlock roots lack this distinctive scent. If you cannot positively identify wild Osha, purchase only from reputable, professional suppliers rather than attempting to wild-harvest.
Energetic Considerations (TCM/Ayurvedic Framework)
In Traditional Chinese Medicine frameworks applied to Western herbs, Osha is considered strongly warming and dispersing. This makes it most appropriate for cold, damp presentations (congestion, chills, sluggish circulation) and potentially aggravating for constitutions running hot and dry (signs of yin deficiency with heat). Individuals who tend toward dryness, heat presentations, or excessive perspiration may want to use Osha in smaller quantities or balance it with cooling, moistening herbs.
Certificate of Analysis and Lab Documentation
Each lot of Sacred Plant Co's Osha Root extract is documented for identity verification and traceable by lot number, with quality records available on request.
Our commitment to transparency means you never have to take our word for quality. Request the COA for any specific batch by emailing us with your lot number.
Request COA by Lot #Not sure how to read a Certificate of Analysis? Our guide breaks down every section. Learn how to read a COA.
Storage and Shelf Life
Store Osha Root glycerite in its amber glass bottle, tightly sealed, in a cool, dark location away from direct sunlight and heat sources. Glycerite extracts typically remain viable for 12 to 24 months when stored properly. Check the aroma, clarity, and best-by date on the label for batch-specific guidance. If the extract develops an off-smell, changes color significantly, or shows visible mold, discard it.
For whole dried Osha Root, store in an airtight container in a cool, dark, and dry environment. Because volatile oil content degrades with exposure to heat, light, and oxygen, proper storage directly impacts the root's potency over time.
Maximize Freshness: Proper storage is the difference between potent extract and expensive dust. Read our complete guide to buying, storing, and using herbs in bulk.
Frequently Asked Questions About Osha Root Tincture
What is the difference between Osha Root tincture and Osha Root glycerite?
A tincture traditionally uses alcohol as the solvent, while a glycerite uses vegetable glycerin. Sacred Plant Co's Osha Root extract is a glycerite, meaning it is alcohol-free. Glycerites offer a naturally sweet taste, making them more palatable for daily use and suitable for individuals who avoid alcohol. While alcohol extracts certain compound classes more efficiently, our year-long Eternal Extraction Method compensates by using extended maceration time and layered infusions to achieve thorough compound transfer into the glycerin base.
How quickly does Osha Root work for respiratory support?
Many users report noticing warming, opening sensations in the throat and chest within 15 to 30 minutes of taking Osha Root glycerite. Traditional practitioners recommend starting Osha at the earliest signs of respiratory discomfort rather than waiting for full symptom development. Keep in mind that individual responses vary, and Osha works best as part of a comprehensive wellness approach rather than as a standalone intervention.
Can I take Osha Root tincture every day?
Most herbalists recommend using Osha Root during acute periods of need rather than as a continuous daily supplement. Short-term, intensive use during seasonal challenges is the most common traditional application. Some practitioners do incorporate low doses into longer-term seasonal protocols, but discuss this approach with a qualified herbalist who can assess your individual constitution and needs.
Is Osha Root the same as Bear Root?
Yes, Osha Root and Bear Root are two common names for the same plant, Ligusticum porteri. The name "Bear Root" derives from traditional observations of bears digging up and consuming the roots after hibernation. Other common names include Porter's Lovage, Mountain Lovage, Chuchupate (in Mexican herbal traditions), and Mountain Ginseng. While over 40 to 60 Ligusticum species exist, only L. porteri is considered "true Osha."
How does Osha Root compare to Echinacea for immune support?
Osha Root and Echinacea support the immune system through different mechanisms and are often used together in comprehensive formulas. Osha acts primarily on the respiratory system through its volatile oils and phthalides. Echinacea works more broadly on systemic immune support. For respiratory-focused concerns, Osha typically takes priority. For general immune concerns, Echinacea may be more appropriate. For a complete decision framework with phytochemistry, traditional uses, and synergy guidance, see our Osha Root vs. Echinacea comparison guide.
Who should avoid Osha Root?
Pregnant and nursing women should avoid Osha Root due to its traditional use as an emmenagogue, and individuals with kidney disease should use caution due to the root's potent aromatic compounds. People taking prescription blood-thinning medications or medications affecting blood sugar should consult their healthcare provider before use. Always discontinue if you experience any adverse reaction, and consult a qualified practitioner before giving Osha to children.
How can I tell if my Osha Root is authentic and not poison hemlock?
The most reliable identification marker is the root's distinctive celery-like aroma. Genuine Osha Root is dark brown, wrinkled, and emits a strong, pleasant scent when broken open. Poison hemlock roots lack this characteristic aroma. Additionally, hemlock stems typically display purple blotching, while Osha stems do not. However, misidentification can be fatal, so we strongly recommend purchasing from reputable suppliers rather than attempting wild harvest unless you have expert-level botanical identification skills.
Explore the Spiritual Dimension: Osha Root carries rich ceremonial significance across Indigenous and Hispano traditions, from Bear Medicine cosmology to the Traveler's Talisman ritual and the Bear's Breath Smudge protocol. While we approach these traditions with respect and cultural sensitivity, understanding Osha's spiritual history deepens appreciation for the plant. Learn about the ceremonial and energetic uses of Osha Root.
Companion Herbs and Continue Through the Bear Root Cluster
Osha Root works exceptionally well alongside complementary respiratory and immune-supporting herbs, and understanding these synergies helps build effective seasonal wellness protocols.
The Complete Osha Library:
- → Bear Root (Osha Root): Complete Science-Based Guide to Benefits and Uses (the cluster pillar)
- → Exploring the Spiritual Uses of Osha Root
- → Osha Root Unearthed: Wildcrafting Ethics & Indigenous Stewardship
- → How to Make Osha Root Tea: Step-by-Step Brewing Guide
- → How to Make Osha Syrup: Step-by-Step Recipe
- → How to Smoke Osha Root (Harm-Reduction Guide)
- → Osha Root vs. Mullein for Respiratory Wellness
- → Osha Root vs. Echinacea: Choosing the Right Immune Ally
- → Osha Root for Seasonal Wellness: A Cold-Month Ritual
Tincture Usage Guide: New to herbal tinctures? Our complete guide covers dosing, timing, and how to incorporate liquid extracts into your daily routine. How to use herbal tinctures effectively.
Conclusion
Osha Root is not a plant that rewards shortcuts, not in its growth (five to seven years in cold mountain soil), not in its harvest (wild-crafted, conservation-sensitive), and not in its extraction (twelve months of patient maceration in our Eternal Extraction process). That is precisely why we believe it is worth the effort. At Sacred Plant Co, our regenerative philosophy teaches us that the best botanical extracts come from systems that are alive, diverse, and given the time they need. Our Osha Root glycerite embodies that philosophy in every drop: responsibly sourced Bear Root, extracted over a full year with four lunar-cycle infusions, bottled alcohol-free for accessible daily use.
Whether you reach for it at the first sign of seasonal respiratory discomfort, brew it into an aromatic Osha syrup, or simply keep a bottle as part of your apothecary essentials, we stand behind the quality and integrity of this extract. And if you ever want to verify that for yourself, just ask for the COA.
This content is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before beginning any new herbal regimen, especially if you are pregnant, nursing, taking medications, or managing a health condition.
References
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- Turi CE, Murch SJ. The Genus Ligusticum in North America: An Ethnobotanical Review with Special Emphasis upon Species Commercially Known as 'Osha.' HerbalGram. 2010;(86):40-51.
- Wilson MF. Medicinal Plant Fact Sheet: Ligusticum porteri / Osha. IUCN Medicinal Plant Specialist Group, PCA-Medicinal Plant Working Group, and North American Pollinator Protection Campaign. 2007.
- Rivero-Cruz JF, Granados-Pineda J, Pedraza-Chaverri J, et al. Quantitative HPLC method for determining two of the major active phthalides from Ligusticum porteri roots. Journal of AOAC International. 2012;95(1):84-91.
- Rivero-Cruz JF, et al. Quantitative HPLC analysis of Z-ligustilide and diligustilide in L. porteri crude drug samples and herbal preparations. J AOAC Int. 2012;95(1):84-91.
- Applequist WL, Brinckmann JA, Cunningham AB, et al. Chemotypic variation in osha (Ligusticum porteri). Biochemical Systematics and Ecology. 2018;79:81-86.
- Andrade-Ochoa S, Villareal KC, Rivera-Chavira BE, Nevárez-Moorillón GV. Antimicrobial Activity of Essential Oil of Ligusticum porteri. Biotecnología y Bioingeniería National Congress. Cancun, Mexico. 2013.
- Ma Z, Bai L. Anti-inflammatory effects of Z-ligustilide nanoemulsion. Inflammation. 2013;36(1):294-299. doi:10.1007/s10753-012-9546-2
- Okoye TC, et al. Effects of Ligusticum porteri (Osha) Root Extract on Human Promyelocytic Leukemia Cells. Pharmacognosy Research. 2017;9(3):281-286. doi:10.4103/pr.pr_110_16
- Velázquez-Moyado JA, Martínez-González A, Linares E, Bye R, Mata R, Navarrete A. Gastroprotective effect of diligustilide isolated from roots of Ligusticum porteri Coulter & Rose (Apiaceae) on ethanol-induced lesions in rats. Journal of Ethnopharmacology. 2015;174:403-409.
- Brindis F, Rodríguez R, Bye R, González-Andrade M, Mata R. (Z)-3-butylidenephthalide from Ligusticum porteri, an alpha-glucosidase inhibitor. Journal of Natural Products. 2011;74(2):314-320.

