Sacred Plant Co bulk stinging nettle leaf (1/2 lb) featuring notes of spinach and green tea, sustainably grown using low-water regenerative Colorado farming techniques.

10 Surprising Health Benefits of Stinging Nettle Leaf You Need to Know Now!

10 Surprising Health Benefits of Stinging Nettle Leaf You Need to Know Now

Last Updated: February 20, 2026

Fresh stinging nettle leaves cultivated in biologically active soil to maximize quercetin and bioavailable mineral uptake. When grown in regenerative soil with active mycorrhizal networks, stinging nettle produces vastly higher concentrations of defense chemicals like quercetin.

It is the quercetin and chlorogenic acid coursing through the veins of a Stinging Nettle leaf that gives it the ability to quell inflammation, calm histamine responses, and flood your body with bioavailable minerals. Urtica dioica is not merely a "vitamin-rich green." It is a living pharmacy whose most powerful compounds are defense chemicals, forged in the interaction between a thriving root system and billions of soil microorganisms. Chemistry created by struggle, not comfort.

These secondary metabolites, the flavonoids, phenolic acids, and lectins that give nettle its legendary sting and its medicinal punch, do not appear in a vacuum. They are the plant's immune response, triggered when mycorrhizal fungi and beneficial bacteria challenge the root zone, forcing the nettle to produce more concentrated chemistry. This is exactly why a nettle leaf grown in sterile, depleted soil tastes flat and performs weakly compared to one cultivated in biologically active earth. At Sacred Plant Co, this understanding drives everything we do. Our commitment to regenerative agriculture, validated by our Haney Score data that surpasses pristine forest benchmarks, is not just a philosophy. It is the mechanism by which we ensure your nettle delivers real potency.


What You'll Learn

  • The key phytochemicals in stinging nettle that drive its ten most researched health benefits
  • How nettle's anti-inflammatory compounds may support joint health, respiratory comfort, and cardiovascular function
  • Why soil biology directly influences the concentration of nettle's medicinal compounds
  • How to identify premium-quality dried nettle leaf using sensory cues
  • Preparation methods, dosage guidelines, and a calming nettle tea recipe with intention
  • Safety considerations, contraindications, and when to consult a healthcare provider
  • How Certificate of Analysis (COA) testing ensures purity and potency in your herbs
  • Nettle's traditional role in European, Ayurvedic, and folk herbal medicine systems

Botanical Profile: Understanding Urtica dioica

A vibrant field of Urtica dioica growing under the sunset on a regenerative farm, ready for a sustainable harvest. Harvesting Urtica dioica at peak maturity ensures the delicate trichomes and potent secondary metabolites remain fully intact for extraction.

Stinging Nettle (Urtica dioica) is a perennial flowering plant in the Urticaceae family, native to Europe, Asia, and North Africa, now naturalized across temperate regions worldwide. The genus name Urtica derives from the Latin urere, meaning "to burn," a direct reference to the formic acid delivered by the fine, hollow trichomes (stinging hairs) on its stems and leaves.1

Nettle grows in dense colonies in nitrogen-rich soils near streams, forest edges, and disturbed land, often reaching three to seven feet tall. Its serrated, heart-shaped leaves grow in opposite pairs, and the plant produces inconspicuous greenish flowers in drooping clusters from late spring through autumn. The entire aerial portion (leaves and stems) is used in herbal medicine, though the leaves are the primary material for teas, infusions, and dried preparations.

In traditional European herbalism, nettle was considered a foundational "blood-building" tonic. Ayurvedic practitioners recognized it for its ability to clear excess kapha and support the kidneys, while Germanic folk medicine applied fresh nettle topically for joint pain in a practice called urtication.2 Today, modern phytochemical analysis has confirmed what traditional healers observed for millennia: nettle is extraordinarily rich in vitamins A, C, K, and B-complex, plus minerals including iron, calcium, magnesium, silica, and potassium.


How to Identify Premium Stinging Nettle Leaf

Premium dried stinging nettle leaf should have a deep, vibrant green color with occasional silver-green undertones, never brown, grey, or yellowed. When you open the bag, the aroma should hit immediately: a sharp, grassy scent with mineral-green depth, reminiscent of fresh hay with an earthy, slightly astringent bite. If there is no aroma, or if it smells musty and flat, the leaf has either been over-dried, stored improperly, or grown in biologically depleted soil.

The texture matters, too. Quality cut-and-sifted nettle should have visible leaf structure with crisp, papery pieces that snap cleanly between your fingers rather than crumbling to dust or bending limply. Dust and excessive stem material are signs of low-grade processing. When brewed, premium nettle produces a rich, jade-green infusion with a full-bodied, mineral-forward taste and a slight grassiness that lingers on the palate. That mineral bite is the bioavailable iron and silica content doing its work.

For long-term quality, store your dried nettle in an airtight container away from light and moisture. For a complete guide to preserving herb potency, see our article on how to buy, store, and use herbs in bulk.


1. Rich Source of Essential Nutrients

An infographic detailing the dense concentration of bioavailable vitamins and chelated minerals found in stinging nettle leaf. Because nettle's minerals are chelated within the plant's organic matrix, they bypass the absorption barriers common to isolated synthetic supplements.

Stinging nettle leaf contains high concentrations of vitamins A, C, K, and several B vitamins, alongside minerals like iron, calcium, magnesium, potassium, and silica, making it one of the most nutrient-dense herbs available.1

What distinguishes nettle from a typical multivitamin is bioavailability. The minerals in nettle are chelated to organic acids and bound within the plant's cellular matrix, which allows the body to absorb them more efficiently than isolated synthetic supplements. A single cup of nettle infusion steeped for four or more hours can deliver meaningful amounts of calcium, iron, and magnesium in forms your digestive system readily recognizes. The antioxidant content, including beta-carotene and various flavonoids, further supports cellular protection against oxidative stress.


2. Reduces Inflammation

Visual breakdown of stinging nettle leaf inhibiting the NF-kB inflammatory signaling pathway and reducing pro-inflammatory cytokines. Caffeic acid malic ester and nettle lectins work systemically to calm the inflammatory cascade rather than merely suppressing local symptoms.

Stinging nettle leaf has demonstrated significant anti-inflammatory activity through its ability to inhibit NF-kB, a key inflammatory signaling pathway, and reduce circulating levels of pro-inflammatory cytokines like TNF-alpha and IL-6.3

The primary anti-inflammatory compounds in nettle include caffeic acid malic ester, quercetin, and various lectins. These work synergistically rather than through a single mechanism, which may explain why nettle's anti-inflammatory effects are broad rather than targeted to a single tissue. Research published in the Journal of Ethnopharmacology has shown that nettle extract inhibits multiple points in the inflammatory cascade, offering a gentler, more systemic approach than conventional anti-inflammatory agents.3 Because the anti-inflammatory compounds in nettle are secondary metabolites produced in response to microbial challenge in the soil, their concentration varies dramatically depending on growing conditions, reinforcing why regenerative cultivation matters.


3. Supports Joint Health and May Ease Arthritis Discomfort

An infographic demonstrating how stinging nettle provides structural joint support through anti-inflammatory action and bioavailable silica. The dual action of internal mineral nourishment and systemic inflammation reduction makes nettle a profound botanical for structural joint integrity.

Clinical studies suggest that stinging nettle may reduce pain and stiffness associated with osteoarthritis, particularly when used alongside conventional treatments, potentially reducing the need for NSAIDs.4

Nettle's joint-supportive properties stem from its combined anti-inflammatory, analgesic, and mineral-rich profile. The traditional practice of urtication, applying fresh nettle directly to painful joints, has been studied in controlled trials with promising results for localized pain relief. A randomized controlled trial published in the Journal of the Royal Society of Medicine found that patients who applied nettle leaf to arthritic joints reported significantly less pain than those using placebo.4 Internal consumption of nettle tea or tincture supports this joint-protective action from within by providing bioavailable silica and calcium, which are essential for cartilage and bone maintenance. For those building a comprehensive joint-support protocol, nettle pairs well with other mineral-rich herbs. Because nettle supports structural tissue from the inside while calming external inflammation, it functions as both a tonic and a targeted remedy.


4. Strengthens Immune System Function

Chart showing how stinging nettle's polysaccharides and flavonoids enhance macrophage activity for robust immune system resilience. Rather than forcing the immune system into overdrive, nettle's complex polysaccharides modulate cellular responses to build long-term seasonal resilience.

Stinging nettle's combination of vitamin C, flavonoids, and polysaccharides supports immune resilience by enhancing both innate and adaptive immune responses.1

Nettle does not simply "boost" immunity in a vague sense. Its vitamin C content supports the production of white blood cells, while its flavonoids, particularly quercetin, modulate immune responses to prevent overreaction (a quality that also makes it useful for allergies). The plant's polysaccharides have been shown to stimulate macrophage activity, enhancing the body's first line of defense. Regular consumption of nettle infusions throughout the cold season is a time-honored practice in European folk herbalism, and modern research continues to validate this traditional application. Rather than reaching for nettle only when you feel ill, consider it a constitutional tonic that builds immune resilience over time.


5. Promotes Healthy Skin

Illustration of stinging nettle functioning as a botanical spring tonic to clear stagnation and support vibrant connective tissue. Providing both the silica required for collagen synthesis and the anti-inflammatory agents to soothe reactivity, nettle addresses skin health at its foundational level.

Nettle's antioxidant, anti-inflammatory, and mineral-rich properties support skin health by soothing conditions like eczema, reducing oxidative damage, and providing the silica and vitamin A needed for tissue repair.5

The connection between nettle and skin health runs deeper than topical application alone. When consumed internally as a tea or infusion, nettle delivers the building blocks for healthy connective tissue, including silica for collagen synthesis and vitamin A for cellular turnover. Its anti-inflammatory action calms systemic inflammation that often manifests as redness, breakouts, or reactive skin conditions. Traditional herbalists have long used nettle as a "spring tonic" for clearing winter stagnation from the blood, and this practice directly benefits skin clarity. For those dealing with persistent skin challenges, a combination approach of internal nettle infusions and topical applications can be particularly effective. Explore how neem and nettle work together in salve form for intensive skin repair.


6. Aids in Detoxification and Supports Kidney Health

Diagram highlighting stinging nettle's potassium-sparing diuretic properties that flush metabolic waste and support optimal kidney function. Unlike synthetic diuretics that strip the body of vital electrolytes, nettle naturally replaces the potassium it mobilizes during the detoxification process.

Stinging nettle acts as a gentle, natural diuretic that supports kidney function by increasing urine output and promoting the elimination of metabolic waste products, uric acid, and excess sodium.6

Nettle's diuretic action is notable because it increases fluid elimination without depleting potassium, a common side effect of pharmaceutical diuretics. This is because nettle itself contains significant potassium, effectively replacing what is lost through increased urination. The European Scientific Cooperative on Phytotherapy (ESCOP) recognizes nettle leaf as a supportive treatment for urinary tract conditions, recommending it as an "irrigation therapy" alongside adequate fluid intake.6 Traditional herbalists have long valued this kidney-supportive quality, categorizing nettle as a blood-purifying herb that helps the body process and eliminate waste more efficiently. Its combination of diuretic and anti-inflammatory properties also makes it relevant for those prone to urinary tract discomfort.


7. Supports Respiratory Health and Seasonal Comfort

Scientific overview of how the quercetin in stinging nettle leaf stabilizes mast cells to prevent histamine release during allergy season. By stabilizing mast cells before they rupture, a strong nettle infusion acts as a preemptive defense mechanism against seasonal respiratory distress.

Stinging nettle has demonstrated natural antihistamine activity, with research suggesting it may reduce the severity of allergic rhinitis symptoms including sneezing, nasal congestion, and itching.7

The quercetin in nettle stabilizes mast cells, preventing the release of histamine that triggers allergic responses. A randomized, double-blind study found that 58% of participants rated nettle effective for allergy relief, with 48% reporting it more effective than their previous allergy medications.7 Unlike conventional antihistamines that often cause drowsiness and dry mucous membranes, nettle supports the respiratory system while maintaining normal mucus production and alertness. Many herbalists recommend beginning nettle consumption six to eight weeks before allergy season to build up the body's resilience. A daily cup of strong nettle infusion during peak pollen months is a classic protocol in naturopathic practice.


8. Supports Blood Circulation and Cardiovascular Health

Infographic explaining how stinging nettle supports red blood cell production and protects endothelial function for cardiovascular health. The natural synergy between nettle's vitamin C and non-heme iron ensures optimal blood building without the digestive sluggishness of synthetic iron tablets.

Nettle's high iron and vitamin C content supports healthy red blood cell production, while preliminary research suggests its compounds may help maintain healthy blood pressure and cholesterol levels.8

Iron-deficiency is one of the most common nutritional deficiencies worldwide, and nettle has been traditionally used as a gentle, plant-based iron source for centuries. The vitamin C present in nettle enhances non-heme iron absorption, creating a naturally synergistic nutritional profile. Beyond iron, nettle's flavonoids and phenolic acids contribute to vascular health by supporting endothelial function and reducing oxidative stress on blood vessel walls. Animal studies have shown that nettle extract may help relax blood vessel walls through nitric oxide-mediated pathways, though human clinical trials are still limited.8 As with all cardiovascular claims, it is important to view nettle as a supportive food-herb rather than a treatment for any diagnosed condition.


9. Promotes Healthy Hair Growth

Visual guide to stinging nettle delivering essential silica and sulfur to hair follicles while potentially inhibiting the 5-alpha-reductase enzyme. Direct application of nettle stimulates local microcirculation in the scalp, delivering keratin-building sulfur directly to compromised hair follicles.

Stinging nettle supports hair health through its rich silica, iron, and sulfur content, which nourish hair follicles, and through compounds that may inhibit 5-alpha-reductase, the enzyme linked to DHT-driven hair loss.9

The silica and sulfur in nettle are essential structural components of keratin, the protein that forms hair strands. When consumed internally as a tea or tincture, these minerals travel to the hair follicle through the bloodstream, providing building blocks for stronger, more resilient hair. Applied topically as a rinse or infused oil, nettle stimulates scalp circulation and delivers nutrients directly to the follicle. Research has focused particularly on nettle root's ability to inhibit 5-alpha-reductase, the enzyme that converts testosterone to DHT, a compound associated with androgenic hair loss.9 For a complete guide to topical application, our step-by-step resource on nettle's role in natural hair growth covers both internal and external protocols in depth.


10. Supports Digestive Health

Infographic detailing stinging nettle's role as a mild bitter tonic and prebiotic fiber source for optimal digestive microbiome health. The gentle astringency of a nettle infusion tones the intestinal barrier while stimulating the gastric juices necessary for complete nutrient absorption.

Stinging nettle supports digestive function through its anti-inflammatory action on the GI tract, its prebiotic fiber content, and its traditional use as a bitter tonic that stimulates digestive secretions.10

Nettle's gentle anti-inflammatory properties extend to the gut lining, where they may help soothe irritation and support the integrity of the intestinal barrier. The fiber and polysaccharides in nettle act as prebiotics, feeding beneficial gut bacteria and promoting a healthy microbiome. Traditional herbalists have categorized nettle as a mild bitter that promotes digestive fire, stimulating the production of bile and gastric juices that improve nutrient absorption. For those experiencing sluggish digestion, bloating, or occasional discomfort, a cup of nettle tea before meals is a simple and traditional protocol. Combined with its rich mineral content, nettle's digestive support contributes to better overall nutrient uptake from the foods you eat.

Eco-friendly kraft paper bag of premium bulk stinging nettle leaf, sustainably farmed to ensure maximum bioactive compound retention.

Stinging Nettle Leaf Bulk

Starting at $13.96
Tasting Notes: Mineral-green depth, grassy with an earthy, slightly astringent finish
Caffeine-Free

Premium dried Urtica dioica leaf, cut and sifted. Ideal for brewing nourishing infusions, creating tinctures, or blending into your favorite herbal formulas.

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Sacred Plant Co's double-strength stinging nettle liquid extract tincture, expertly crafted for rapid absorption and daily mineral support.

Stinging Nettle Tincture

Starting at $9.99
Tasting Notes: Concentrated, herbaceous green with a sharp, earthy bite
Caffeine-Free

Double-strength Urtica dioica liquid extract for fast absorption. A convenient option for daily supplementation when brewing tea is not practical.

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Preparation Methods and Dosage Guidelines

The standard dosage for dried stinging nettle leaf is 1 to 3 teaspoons steeped in 8 ounces of just-boiled water for 10 to 15 minutes for a standard tea, or 1 ounce of dried leaf steeped in a quart of boiled water for 4 or more hours for a full-strength nourishing infusion.


Nettle Leaf Tea (Standard Infusion)

Place 1 to 2 teaspoons of dried nettle leaf in a tea infuser or directly in your cup. Pour just-boiled water over the herb and steep for 10 to 15 minutes. Strain and drink. This method is ideal for daily enjoyment and delivers a lighter mineral and vitamin profile. Drink 1 to 3 cups daily.


Nourishing Herbal Infusion (Full-Strength)

Place 1 ounce (approximately one cup by volume) of dried nettle leaf in a quart-sized mason jar. Fill with boiling water, cap tightly, and let steep for 4 to 8 hours or overnight. Strain and drink throughout the day, refrigerating any unused portion. This method extracts significantly more minerals and nutrients than a standard tea. Herbalist Susun Weed popularized this technique as a cornerstone of her nourishing traditions approach.


Tincture

For a concentrated liquid extract, take 1 to 2 dropperfuls (approximately 30 to 60 drops) of nettle tincture in a small amount of water, 2 to 3 times daily. Tinctures offer convenience and faster absorption, making them practical for on-the-go supplementation.


Ritual and Intention

Nettle has a fierce, protective energy in traditional herbalism, often associated with boundary-setting and resilience. As you prepare your nettle tea, consider pausing to set an intention. The simple act of steeping and waiting is itself a practice in patience. Allow the steeping time to become a moment of stillness in your day, connecting the nourishment entering your body with a conscious acknowledgment of the earth that produced it.


Recipe: Calming Nettle and Peppermint Tea

This simple blend pairs nettle's mineral-rich depth with the bright, cooling relief of peppermint for a soothing cup that supports digestion and calm.

A steaming glass teapot of calming stinging nettle and peppermint tea, showcasing the rich, jade-green infusion of bioavailable minerals. Blending nettle with a cooling botanical like peppermint softens its earthy astringency while compounding its digestive and respiratory benefits.

Ingredients:

Instructions:

  1. Combine nettle and peppermint in a tea infuser or directly in your cup.
  2. Pour 8 ounces of just-boiled water over the herbs.
  3. Steep for 5 to 7 minutes. For a stronger mineral extraction, extend to 10 minutes.
  4. Strain, add honey or lemon if desired, and enjoy.

This blend works well as a mid-morning or afternoon ritual. The peppermint's menthol complements nettle's mineral body without overpowering it, and together they support both digestive comfort and gentle respiratory opening.


Safety Considerations and Contraindications

Stinging nettle leaf is generally well-tolerated when consumed as a food or tea, but it may interact with blood-thinning medications, diuretics, blood pressure medications, and diabetes drugs due to its pharmacologically active compounds.


Important Safety Information

Contraindications (Medical Interactions):

  • Blood-thinning medications (Warfarin, Aspirin): Nettle is high in vitamin K, which promotes blood clotting and can counteract anticoagulant therapy. Consult your healthcare provider before use.
  • Diuretic medications: Nettle's natural diuretic action may compound the effects of pharmaceutical diuretics, increasing the risk of dehydration or electrolyte imbalance.
  • Blood pressure medications: Nettle may lower blood pressure, potentially amplifying the effects of antihypertensive drugs.
  • Diabetes medications: Nettle may lower blood sugar levels, requiring dose adjustments for those on insulin or oral hypoglycemics.
  • Pregnancy: Nettle leaf tea is traditionally used in pregnancy (particularly in the third trimester as a nutritive tonic), but it should only be used during pregnancy under the guidance of a qualified healthcare provider or experienced herbalist due to its potential uterine-stimulating effects.

Energetics (Traditional Context): In traditional Western herbalism, nettle is classified as cooling and drying. Individuals who already tend toward coldness and dryness may wish to balance nettle with warming, moistening herbs like ginger or licorice root. Nettle is considered astringent and tonifying, making it most appropriate for constitutions with excess heat, dampness, or stagnation.

General Guidance: Start with small amounts (one cup of tea daily) to assess your body's response. If you experience any digestive discomfort, reduce your intake or discontinue use. Always consult a qualified healthcare provider before adding any herbal supplement to your routine, especially if you are pregnant, breastfeeding, or managing a medical condition.


Transparency You Can Trust: Certificate of Analysis

Every batch of our herbs undergoes independent lab testing for purity, potency, and contaminants. We believe transparency is the foundation of trust, and we make our testing data available to you.

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Want to understand what lab reports actually tell you? Read our guide on how to read a Certificate of Analysis.


Frequently Asked Questions About Stinging Nettle Leaf


What are the main health benefits of stinging nettle leaf?

Stinging nettle leaf is best known for reducing inflammation, supporting joint health, providing antihistamine relief for seasonal allergies, delivering bioavailable vitamins and minerals (especially iron, calcium, and silica), promoting healthy hair growth, and supporting kidney and digestive function. Its broad nutrient profile and diverse phytochemistry make it one of the most versatile herbs in traditional Western herbalism.


How do you make stinging nettle tea?

To make stinging nettle tea, steep 1 to 2 teaspoons of dried nettle leaf in 8 ounces of just-boiled water for 10 to 15 minutes, then strain and drink. For a full-strength nourishing infusion, use 1 ounce of dried leaf per quart of boiled water and steep for 4 to 8 hours. Mastering this technique unlocks significantly more minerals. Our detailed guide on brewing the perfect stinging nettle tea covers timing, temperature, and flavor variations.


Is stinging nettle safe to consume daily?

Yes, stinging nettle leaf tea is generally considered safe for daily consumption by most healthy adults when taken in standard dietary amounts (1 to 3 cups of tea per day). However, individuals taking blood-thinning medications, diuretics, blood pressure drugs, or diabetes medications should consult a healthcare provider before regular use due to potential interactions.


Can stinging nettle help with allergies?

Research suggests that stinging nettle may reduce symptoms of allergic rhinitis, including sneezing, nasal congestion, and itching, due to its quercetin content, which stabilizes mast cells and inhibits histamine release. A clinical study found that 58% of participants rated nettle as effective for allergy relief. Many herbalists recommend starting daily nettle consumption 6 to 8 weeks before allergy season for best results.


Does stinging nettle contain caffeine?

No, stinging nettle is completely caffeine-free. It makes an excellent choice for those seeking a nourishing herbal infusion without stimulant effects. Nettle tea can be enjoyed at any time of day, including the evening, without disrupting sleep.


What does premium dried stinging nettle look like?

Premium dried stinging nettle leaf should be a vibrant, deep green color with visible leaf structure and a strong, fresh, grassy aroma with mineral-green depth. Avoid nettle that is brown, grey, or yellowed, has no aroma, or crumbles to fine dust, as these are indicators of age, poor drying methods, or degraded potency.


Can I use stinging nettle for hair growth?

Stinging nettle supports hair health through its silica, iron, and sulfur content, which nourish hair follicles, and through compounds that may inhibit the enzyme linked to DHT-driven hair loss. It can be consumed as a tea or tincture for internal support, and applied topically as a hair rinse or nettle-infused oil for direct scalp nourishment.


Continue Your Nettle Journey


Conclusion

Stinging nettle leaf is not a trend or a novelty. It is one of the most deeply researched, nutritionally dense, and traditionally revered herbs on the planet. Its ten most compelling benefits, from reducing inflammation and supporting respiratory health to nourishing hair and strengthening bones, are driven by the same phytochemical complexity that has made Urtica dioica a cornerstone of herbalism for thousands of years.

But here is the part that matters most: not all nettle is created equal. The concentration of quercetin, chlorogenic acid, mineral content, and the aromatic compounds that mark a truly potent leaf are all products of how the plant was grown. Sterile, depleted soil produces a flat, lifeless herb. Living, microbially active soil produces medicine. At Sacred Plant Co, this is the principle behind everything we offer. We do not just sell herbs. We steward the soil that creates them.

Whether you are steeping your first cup of nettle tea or building it into a long-term wellness protocol, you deserve an herb that works. Start with quality. Start with intention. And let the nettle do what it has always done best: nourish.


References

  1. Upton, R. (Ed.). (2013). Stinging Nettles Leaf (Urtica dioica L.): Extraordinary Vegetable Medicine. Journal of Herbal Medicine, 3(1), 9-38. https://doi.org/10.1016/j.hermed.2012.11.001
  2. Bone, K., & Mills, S. (2013). Principles and Practice of Phytotherapy: Modern Herbal Medicine (2nd ed.). Churchill Livingstone/Elsevier.
  3. Riehemann, K., Behnke, B., & Schulze-Osthoff, K. (1999). Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kB. FEBS Letters, 442(1), 89-94. PubMed
  4. Randall, C., Randall, H., Dobbs, F., Hutton, C., & Sanders, H. (2000). Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. Journal of the Royal Society of Medicine, 93(6), 305-309. PubMed
  5. Gupta, A., & Singh, S. (2014). Evaluation of anti-inflammatory effect of Urtica dioica leaf extract against dermal inflammation. International Journal of Pharmacological Sciences, 6(1), 281-283.
  6. European Scientific Cooperative on Phytotherapy (ESCOP). (2003). ESCOP Monographs: Urticae Folium (2nd ed.). Thieme.
  7. Mittman, P. (1990). Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Medica, 56(1), 44-47. PubMed
  8. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., & Ziyyat, A. (2000). Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. Journal of Ethnopharmacology, 73(1-2), 95-100. PubMed
  9. Nahata, A., & Dixit, V.K. (2014). Evaluation of 5-alpha reductase inhibitory activity of certain herbs useful as antiandrogens. Andrologia, 46(6), 592-601. PubMed
  10. Gul, S., Ahmed, S., Kifli, N., Uddin, Q.T., Batool Tahir, N., Hussain, A., ... & Choudhary, M.I. (2014). Multiple pathways are responsible for anti-inflammatory and cardiovascular activities of Urtica dioica leaf extract. Food and Chemical Toxicology, 69, 22-30.

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